tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 21959459, compound

HRID 2109644Notes

Reaction equation

HRID 2109644 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([NH:12][C:13](=[O:30])[C:14]2[CH:19]=[CH:18][CH:17]=[N:16][C:15]=2[NH:20][C:21]2[CH:29]=[C:28]3[C:24]([CH:25]=[N:26][NH:27]3)=[CH:23][CH:22]=2)[CH:5]=[CH:6][C:7]=1[C:8]([CH3:11])([CH3:10])[CH3:9].[C:31]([N:38]1[CH2:43][CH2:42][C:41](=O)[CH2:40][CH2:39]1)([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32]>>[C:8]([C:7]1[CH:6]=[CH:5][C:4]([NH:12][C:13](=[O:30])[C:14]2[CH:19]=[CH:18][CH:17]=[N:16][C:15]=2[NH:20][C:21]2[CH:29]=[C:28]3[C:24]([CH:25]=[N:26][NH:27]3)=[CH:23][CH:22]=2)=[CH:3][C:2]=1[NH:1][CH:41]1[CH2:42][CH2:43][N:38]([C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[CH2:39][CH2:40]1)([CH3:11])([CH3:10])[CH3:9]

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 21959454HCID 21959454, compound

Product 1

HCID 21959459HCID 21959459, compound

Procedure

The title compound was prepared from N-(3-amino-4-tert-butyl-phenyl)-2-(1H-indazol-6-ylamino)-nicotinamide and Boc-piperidin-4-one by a method analogous to that described in Example 42. MS (ES+): 584 (M+H), Calc'd for C33H41N7O3−583.7.

Sources & evidence

ORD record
ord-1c7f7f3d27994e2d97762c964e32389a
Source dataset
uspto-grants-2009_04
Patent number
US07514564B2

Reaction notes

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