Methanesulfonic Acid → HCID 57634629, compound

Participants

Reaction Steps

To a solution of methanesulfonic acid (314 g) in dichloromethane (10 L) at room temperature, a solution of N2-acetyl-N1-(2,2-dimethoxyethyl)-N1-(4-fluoro-benzyl)glycinamide (438 g, 1.07 mol) in dichloromethane (2 L) was added slowly over a period of 2 h. The reaction mixture was stirred at room temperature overnight and treated with saturated aqueous sodium carbonate (3 L). The organic extract was washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. To the residual oil, ethyl acetate (1 L) was added and stirred at room temperature. The solid precipitated was filtered to provide the title compound.

Provenance & Evidence