N-bromobutanimide → HCID 54718140, compound

Participants

Reaction Steps

To a suspension of 2-(4-fluorobenzyl)-8,9-dihydroxy-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione (0.1 g, 0.33 mmol) in chloroform (5 mL), N-bromo-succinimide (64 mg, 0.36 mmol) was added and stirred at room temperature overnight. The product mixture was concentrated and the residue was subjected to HPLC purification on C-18 stationary phase eluted with water/acetonitrile/TFA mobile phase. Collection and lyophilization of appropriate fractions provided the title compound as white solid.

Provenance & Evidence