Formaldehyde → HCID 54715338, compound

Participants

Reaction Steps

A mixture of 2-(4-fluorobenzyl)-8,9-dihydroxy-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione (0.2 g, 0.66 mmol), piperidine (0.13 mL, 1.3 mmol), and formaldehyde (0.08 mL, 37% solution in water) in absolute ethanol (5 mL) was stirred at room temperature for 6 h. The product mixture was concentrated under vacuum, and the residue was subjected to HPLC purification on C-18 stationary phase eluted with water/acetonitrile/TFA mobile phase. Collection and lyophilization of appropriate fractions provided the title compound.

Provenance & Evidence