反应详情

A mixture of 2-(4-fluorobenzylamino)-3-nitropyridine (1.0 g, 4.05 mmol) and 10% Pd/C (0.3 g) in methanol (50 mL) was stirred under an atmosphere of hydrogen (1 atm) at room temperature for 5 hours. The product mixture was filtered through a pad of Celite, and concentrated under vacuum. The residual methanol was removed by co-evaporation with benzene. The resultant N2-(4-Fluorobenzyl)pyridine-2,3-diamine was used in the following step without further purification.

1. filtrationThe product mixture was filtered through a pad of Celite
2. concentrationconcentrated under vacuum
3. customThe residual methanol was removed by co-evaporation with benzene
4. customThe resultant N2-(4-Fluorobenzyl)pyridine-2,3-diamine was used in the following step without further purification