(Pyridin-4-yl)boronic acid → 8-Chloro-11-(pyridin-4-yl)-5h-dibenzo[b,e][1,4]diazepine

HRID 2109913Notes

Reaction equation

HRID 2109913 reaction equation
B(O)(O)[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[Cl:10][C:11]1[CH:12]=[CH:13][C:14]2[N:20](Cl)[C:19]3[CH:22]=[CH:23][CH:24]=[CH:25][C:18]=3[CH:17]=[N:16][C:15]=2[CH:26]=1>>[Cl:10][C:11]1[CH:12]=[CH:13][C:14]2[NH:20][C:19]3[CH:22]=[CH:23][CH:24]=[CH:25][C:18]=3[C:17]([C:2]3[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=3)=[N:16][C:15]=2[CH:26]=1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 574854318,5-Dichloro-5H-dibenzo[b,e][1,4]diazepine

Product 1

HCID 1356206818-Chloro-11-(pyridin-4-yl)-5h-dibenzo[b,e][1,4]diazepineYield 30.4%

Procedure

4 pyridyl-4-boronic acid (14 mg, 0.12 mmol) and 8,5-dichloro-5H-dibenzo[b,e][1,4]diazepine (160FE64) (26 mg, 0.1 mmol) were reacted according GP11 to give 9.3 mg of the title compound (160FE69A). MS (ESI) 306 (MH+). Purity for MH+ (UV/MS) 98/95.

Sources & evidence

ORD record
ord-ca014baffbb44b7da8bffd09dec4603b
Source dataset
uspto-grants-2009_04
Patent number
US07517871B2

Reaction notes

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