4-Methyl-4-[2-(2-nitrophenoxy)ethyl]morpholin-4-ium methylsulfate → 4-[2-(2-Aminophenoxy)ethyl]-4-methylmorpholin-4-ium methylsulfate

Participants

Reaction Steps

2.08 g (5.5 mmol) of the compound from Step 5.2 was dissolved in 80 mL of ethanol and hydrogenated in the presence of 0.25 g of Pd/C (10%) under 9 bar of hydrogen pressure. After 2 hours, the catalyst was filtered off and the filtrate was evaporated to dryness. This gave 1.9 g (99% of the theoretical) of a colorless oil which was subjected to further reaction without additional purification.

Provenance & Evidence