Dimethyl Sulfate → HCID 86069929, compound

Participants

Reaction Steps

5.0 g (22.4 mmol) of the free amine from Step 10.2 was dissolved in 50 ml of acetonitrile and to this solution was added dropwise with agitation over a period of 10 min 2.83 g (22.4 mmol) of dimethyl sulfate. The reaction temperature gradually rose to 45° C. and a precipitate formed. After an agitation period of 3 hours, the mixture was filtered and the filter cake was washed with a small amount of acetonitrile and then dried at 40° C. under vacuum.

Provenance & Evidence