N,N-Dimethylaniline → HCID 57635942, compound

Participants

Reaction Steps

A solution of compound (4) (6.0 g, 17.7 mmol) and N,N-dimethylaniline (2.24 mL, 17.7 mmol) in phosphorus oxychloride (20 mL) was heated to reflux in a sealed tube for 1 h. Solvent was removed and the residue was dissolved in EtOAc (200 mL) and washed with saturated aqueous NaHCO3, dilute HCl, followed by brine, dried over anhydrous Na2 SO4, filtered and concentrated to give 5-(2-benzylsulfanyl-4-chloro-pyrazolo[1,5-a][1,3,5]triazin-8-yl)-pentanenitrile (5), which was used directly for the next step.

Provenance & Evidence