Ethyl 3-aminobenzoate → HCID 57635949, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound (13a) (1.24 g, 4.62 mmol) in 10 mL of ethanol was added ethyl 3-aminobenzoate (764 mg. 4.62 mmol). The reaction mixture was heated at 50° C. for 2 h and then cooled to room temperature. Solvent was removed and the residue was dissolved in EtOAc (50 mL) and washed with saturated aq NaHCO3, 10% HCl, and brine and dried over anhydrous Na2 SO4. Removal of the solvent provided a residue that was purified by flash column with use of EtOAc/hexane (25% to 50%) to yield 3-[5-chloro-3-(4-cyano-butyl)-pyrazolo[1,5-a]pyrimidin-7-ylamino]-benzoic acid ethyl ester (14a) (1.0 g. 50%).

Provenance & Evidence