M-Phenylenediamine → HCID 57635951, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound (14a) (0.63 g. 1.6 mmol) and benzene-1,3-diamine (69 mg, 0.636 mmol) in 2 mL of NMP was heated at 160° C. overnight. The reaction mixture was diluted with EtOAc (50 mL) and washed with saturated aq NaHCO3 and brine and dried over anhydrous Na2 SO4. HPLC purification provided 3-[5-(3-amino-phenylamino)-3-(4-cyano-butyl)-pyrazolo[1,5-a]pyrimidin-7-ylamino]-benzoic acid ethyl ester (15a) (0.37 g. 50%).

Provenance & Evidence