N-methyl-2-pyrrolidone → HCID 86619124, compound

Participants

Reaction Steps

To a mixture of compound (17 a) (35 mg, 0.075 mmol), DIEA (50 μL) in 1 mL of NMP was added HATU (50 mg, 0.12 mmol). The reaction mixture was sonicated for 2 min, and allowed to stand for 0.5 h at room temperature After which, dimethyl-pyrrolidin-3-yl-amine (15 μL. 0.1 mmol) was added, followed by additional HATU (5 mg. 0.12 mmol). The reaction mixture was stirred at room temperature for 0.5 h. Preparative RP-HPLC purification provided (11,14)3,5N-{[(3-dimethylamino-pyrrolidine-1-carbonyl)-phen-3-yl]pyrazolo[1,5-a]pyrimidin-2,4-yl-diamino}-(2N,4N)-phenyl-1,5-diaza-cyclotetradecan-6-one (18a) (15 mg).

Provenance & Evidence