Imidazole → HCID 86610505, compound

Participants

Reaction Steps

After dissolving C-[1-(3,4-dichloro-benzyl)-piperidin-4-yl]-methylamine (80 mg) in acetonitrile (2 ml), thiocarbonyldiimidazole (80 mg) and imidazole (6 mg) were added at 0° C. The mixture was stirred at room temperature for 2 hours and 30 minutes, and then 3-nitro-1,2-phenylenediamine (66 mg) was added and the temperature was raised to 50° C. prior to stirring for 12 hours. The reaction mixture was filtered, the solvent was removed under reduced pressure, and the obtained residue was purified by thin-layer silica gel chromatography (hexane/ethyl acetate/dichloromethane/methanol=60/25/10/5) to obtain 1-(2-amino-phenyl-3-[1-(3,4-dichloro-benzyl)-piperidin-4-ylmethyl]-thiourea. The compound was identified by LC-MS.

Provenance & Evidence