Water → HCID 69065334, compound

Participants

Reaction Steps

After adding 1-naphthoaldehyde (3 mmol) and sodium triacetoxyborohydride (3 mmol) to a solution of (4-nitro-1H-benzimidazol-2-yl)-piperidin-4-ylmethyl-amine (450 mg, 1 mmol) in dimethylformamide-acetic acid (10:1) (7 mL), the mixture was stirred at room temperature overnight. Water and dichloromethane were added, and extraction was performed with dichloromethane. The solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/triethylamine=100/0→98/2) to obtain (1-naphthalen-1-ylmethyl-piperidin-4-ylmethyl)-(4-nitro-1H-benzimidazol-2-yl)-amine. The compound was identified by LC-MS.

Provenance & Evidence