Methyl 2-amino-3-nitrobenzoate → 2,3-Diaminobenzoic acid methyl ester

Participants

Reaction Steps

After dissolving 2-amino-3-nitrobenzoic acid methyl ester (661 mg, 3.37 mmol) in methanol (30 ml), 10% palladium-carbon powder (5 mol %) was added under a nitrogen stream, and the mixture was stirred for 1 hour under a hydrogen atmosphere. The reaction mixture was filtered through celite, and the obtained filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane/ethyl acetate=2/1) to obtain 2,3-diaminobenzoic acid methyl ester. The compound was identified by NMR.

Provenance & Evidence