Ammonia → 9-methyl-8-phenylpurine-6-ylamine

HRID 2110102Notes

Reaction equation

HRID 2110102 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[N:6]2[CH3:11].[NH3:18]>>[CH3:11][N:6]1[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:4][C:3]2[C:7]1=[N:8][CH:9]=[N:10][C:2]=2[NH2:18]

Participants

3

Reactant 2

HCID 222Ammonia2×HCID 11230310HCID 11230310, compound

Product 1

HCID 3085319-methyl-8-phenylpurine-6-ylamine

Conditions

Temperature
-196 °C

Procedure

6-chloro-9-methyl-8-phenylpurine was added in a steel vial to ammonia cooled to −196° C. using liquid nitrogen. The reaction mixture was allowed to warm to 16° C. for 70 hours; after that, the ammonia was allowed to evaporate at room temperature and the residue was chromatographed and/or crystallized to give 9-methyl-8-phenylpurine-6-ylamine, a compound of Formula (I).

Workup

  1. temperatureto warm to 16° C. for 70 hours
  2. customto evaporate at room temperature
  3. customthe residue was chromatographed
  4. customcrystallized

Sources & evidence

ORD record
ord-00ada8958a4a4830b744c69d3179b0a2
Source dataset
uspto-grants-2009_04
Patent number
US07517888B2

Reaction notes

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