HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl 4-nitro-2,3-dihydro-1H-indene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | Dimethyl 4-nitro-1H-indene-2,2(3H)-dicarboxylate | HCID 57565181 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl 4-nitro-2,3-dihydro-1H-indene-2-carboxylate | HCID 53415165 | 67.7% |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
A mixture of dimethyl-4-nitroindane-2,2-dicarboxylate (4.84 g, 0.0167 mol), lithium chloride (0.84 g, 0.0198 mol), 1.1 mL water, and 18 mL dimethylsulfoxide was heated to 160° C. under nitrogen for two hours. It was then allowed to cool and the dimethylsulfoxide was removed under high vacuum. The residue was purified on silica (10%-100% CH2Cl2 in hexanes) to give 2.5 g white solid (65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07517884B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-1956b8a95eb64db99964431bdb57110f |
| Source note | uspto-grants-2009_04 |