反应详情

A mixture of intermediate 20A (1.20 g, 4.31 mmol) and 10% palladium on carbon (300 mg) in MeOH (30 mL) was hydrogenated with a Parr shaker under 55 psi of hydrogen gas for 3 h. After filtration through celite, the filtrate was evaporated and azeotroped with EtOAc to give the desired intermediate 20B as white solid (quant. yield).LCMS (+ESI) m/z 145.1 [M+H]+.

1. filtrationAfter filtration through celite
2. customthe filtrate was evaporated
3. customazeotroped with EtOAc