Dimethylformamide → HCID 57635097, compound

Participants

Reaction Steps

To a solution (S)-3,3-dimethyl-2-(7-methyl-3-phenyl-5,6,7,8-tetrahydroimidazo [1,5-a]pyrazine-1-carboxamido)butanoic acid (Compound 281) (0.11 g. 0.30 mmol) in DCM was added oxalyl chloride (0.08 g, 0.60 mmol) followed by a catalytic amount of DMF. The resulting mixture was stirred for 2 h and the solvent was evaporated, toluene (2 mL) was added and the mixture was concentrated again. The resulting product (Intermediate 23A) was dried under vacuum and then used in the next step without further purification.

Provenance & Evidence