Potassium Phosphate, Tribasic → HCID 72799477, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 281A (27 mg, 50 umol) in 1 mL dioxane was added 2M solution of K3PO4 (100 uL), Pd(PPh3)4 (3 mg, 2 umol) and the contents were degassed and purged with nitrogen. To this solution was added 3-thiophene boronic acid (7 mg, 55 umol) and the resulting mixture was heated in a sealed 1 dram vial at 110° C. for 48 h. Contents were cooled to room temperature and passed through a waters HLB u elution plate to get rid of insoluble material and the filtrate was further purified via prep HPLC (Xterra 10×50 mm, S5 column, MeOH— Water gradient) to give the title compound. HPLC retention time (2.04 min). Observed mass 576.13.

Provenance & Evidence