Potassium Phosphate, Tribasic → HCID 57636437, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-Iodo-6-nitro-indazole-1-carboxylic acid tert-butyl ester (5.83 g, 14.98 mmol) in 200 mL toluene was added 2-chlorophenyl boronic acid (4.48 g, 28.46 mmol), K3PO4 (7.82 g), Pd2(dba)3 (41.53 mg) and 2-(dicyclohexylphosphino)-2′-methylbiphenyl) (436.68 mg). The reaction mixture was heated to 110° C. and stirred at this temperature for 36 hours. The reaction mixture was cooled and partitioned between water and EtOAc. The orgaic layer was separated, dried over MgSO4, filtered and concentrated under reduced pressure to give 8.82 g of crude 3-(2-Chloro-phenyl)-6-nitro-1H-indazole, MS (M+H)=275.

Provenance & Evidence