HCID 57636446, compound → HCID 57636448, compound

Participants

Reaction Conditions

Reaction Steps

Isopropyl-(6-nitro-1H-indazol-3-yl)-amine (0.070 g, 0.318 mmol) and SnCL2.2H2O (0.365 g, 1.62 mmol) were added to 5 mL EtOH, and the reaction mixture was heated to 78° C. and stirred for four hours. The reaction mixture was cooled and concentrated under reduced pressure. The resulting oil was dissolved in 5 mL EtOH and the solution was treated with 5 mL saturated aqueous NaHCO3. The resulting solid was removed by filtration, and the filtrate was washed with saturated aqueous NaHCO3, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was chromatographed through silica gel (EtOAc/hexanes 0-100%) to give 0.036 g of N*3*-Isopropyl-1H-indazole-3,6-diamine, MS (M+H)=219.

Provenance & Evidence