Pyridine → HCID 178452652, compound

Participants

Reaction Steps

A solution of 1.5 g of tert-butyl [4-(3-amino-7-fluoro-1H-indazol-6-yl)-2-fluoro -phenyl]carbamate in 34 mL of pyridine is admixed at 15° C. with 0.61 g of thiophene-3-carbonyl chloride. The reaction mixture is stirred for 18 h and then poured into distilled water and extracted with ethyl acetate. The organic phase is washed a number of times with distilled water and then with saturated aqueous sodium chloride solution, dried over magnesium sulfate and then concentrated to dryness under reduced pressure. This gives 1.58 g of (7-fluoro-6-{3-fluoro-4-tert-butyloxycarbonylaminophenyl}-1H-indazol-3-yl)thiophene-3-carboxamide in the form of a cream-colored solid, whose characteristics are as follows:

Provenance & Evidence