Aluminium lithium hydride → HCID 58737516, compound

HRID 2110296Notes

Reaction equation

HRID 2110296 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]([N:14]3[CH2:19][CH2:18][CH2:17][CH:16]([CH2:20][O:21][C:22]4[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=4)[CH2:15]3)=O)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([CH2:12][N:14]3[CH2:19][CH2:18][CH2:17][CH:16]([CH2:20][O:21][C:22]4[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=4)[CH2:15]3)[CH2:9][CH2:10][CH2:11]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21901973HCID 21901973, compound

Product 1

HCID 58737516HCID 58737516, compoundYield 49.5%

Procedure

Compound 86 was synthesized from compound 84 (0.50 g, 1.25 mmol) and lithium aluminum hydride (0.10 g), using the method described for the synthesis of compound 83 to give 0.24 g of the desired product 86. C23H27ClFNO, LRMS (m/z)=388 (MH+).

Sources & evidence

ORD record
ord-c19f8217c3f4450b8eadedf96d735224
Source dataset
uspto-grants-2009_04
Patent number
US07517892B2

Reaction notes

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