Aluminium lithium hydride → HCID 58737529, compound

HRID 2110297Notes

Reaction equation

HRID 2110297 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]([N:14]3[CH2:19][CH2:18][CH2:17][CH:16]([CH2:20][O:21][C:22]4[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=4)[CH2:15]3)=O)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:12][N:14]3[CH2:19][CH2:18][CH2:17][CH:16]([CH2:20][O:21][C:22]4[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=4)[CH2:15]3)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21901945HCID 21901945, compound

Product 1

HCID 58737529HCID 58737529, compoundYield 41%

Procedure

Compound 87 was synthesized from compound 85 (0.50 g, 1.25 mmol) and lithium aluminum hydride (0.10 g), using the method described for the synthesis of compound 83 to give 0.19 g of the desired product 87. C22H27ClN2O, LRMS (m/z)=371 (MH+).

Sources & evidence

ORD record
ord-ce0375c6db4d42ed813b278c85015e31
Source dataset
uspto-grants-2009_04
Patent number
US07517892B2

Reaction notes

Loading…