HCID 57636353, compound → HCID 68906271, compound

HRID 2110377Notes

Reaction equation

HRID 2110377 reaction equation
[NH2:1][CH2:2][C@@H:3]([OH:22])[C@@H:4]([N:11]1[C:19]2[C:14](=[CH:15][C:16]([Cl:20])=[CH:17][CH:18]=2)[C:13]([CH3:21])=[CH:12]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.ClC1C=C2C(=CC=1)N([C@@H](C1C=CC=CC=1)[C@H](O)CO)C=C2C>>[ClH:20].[NH2:1][CH2:2][C@@H:3]([OH:22])[C@@H:4]([N:11]1[C:19]2[C:14](=[CH:15][C:16]([Cl:20])=[CH:17][CH:18]=2)[C:13]([CH3:21])=[CH:12]1)[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 57636353HCID 57636353, compoundHCID 68904807HCID 68904807, compound

Product 1

HCID 68906271HCID 68906271, compound

Procedure

In an analogous manner to EXAMPLE 118, (1S,2R)-3-amino-1-(5-chloro-3-methyl-1H-indol-1-yl)-1-phenylpropan-2-ol was prepared from (2S,3S)-3-(5-chloro-3-methyl-1H-indol-1-yl)-3-phenylpropane-1,2-diol (EXAMPLE 119, step 4). MS (ES) m/z 315.1

Sources & evidence

ORD record
ord-5ec2667264cb44e68ca0089d9080ad61
Source dataset
uspto-grants-2009_04
Patent number
US07517899B2

Reaction notes

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