HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Fluoroindole → (2S,3S)-3-(6-fluoro-1H-indol-1-yl)-3-(3-fluorophenyl)propane-1,2-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Fluoroindole | HCID 351278 | — |
| Reactant | [(2R,3R)-3-(3-fluorophenyl)oxiran-2-yl]methanol | HCID 45142226 | — |
| Product | (2S,3S)-3-(6-fluoro-1H-indol-1-yl)-3-(3-fluorophenyl)propane-1,2-diol | HCID 68903046 | — |
Reaction Steps
In an analogous manner to EXAMPLE 117, step 5. (2S,3S)-3-(6-fluoro-1H-indol-1-yl)-3-(3-fluorophenyl)propane-1,2-diol was prepared from 6-fluoro-1H-indole and [(2R,3R)-3-(3-fluorophenyl)oxiran-2-yl]methanol (EXAMPLE 47 step 3). MS (ESI) m/z 304.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07517899B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-2ba8a0cd37844438b4934995a7ccbfe7 |
| Source note | uspto-grants-2009_04 |