HCID 44231251, compound → HCID 68906880, compound

HRID 2110392Notes

Reaction equation

HRID 2110392 reaction equation
[ClH:1].[CH2:2]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([C@@H:13]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)[C@H:14]([OH:18])[CH2:15][NH:16][CH3:17])[C:5]1=[O:26])[CH3:3].C(N1C2C=CC=CC=2N([C@@H](C2C=CC=C(F)C=2)[C@H](O)CO)C1=O)C>>[ClH:1].[CH2:2]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([CH:13]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)[CH:14]([OH:18])[CH2:15][NH:16][CH3:17])[C:5]1=[O:26])[CH3:3]

Participants

3

Reactant 2

HCID 44231251HCID 44231251, compoundHCID 44254775HCID 44254775, compound

Product 1

HCID 68906880HCID 68906880, compound

Procedure

In an analogous manner to EXAMPLE 192, step 4 1-ethyl-3-[(1S,2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-1,3-dihydro-2H-benzimidazol-2-one hydrochloride was prepared from 1-ethyl-3-[(1S,2S)-2,3-dihydroxy-1-(3-fluorophenyl)-propyl]-1,3-dihydro-2H-benzimidazol-2-one as a white solid. MS (ES) m/z 344.2

Sources & evidence

ORD record
ord-01d76b55babc49e295f6093d56ee1a31
Source dataset
uspto-grants-2009_04
Patent number
US07517899B2

Reaction notes

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