HCID 44254961, compound → HCID 68903007, compound

HRID 2110393Notes

Reaction equation

HRID 2110393 reaction equation
[ClH:1].[F:2][C:3]1[C:11]2[N:10]([C@@H:12]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C@H:13]([OH:17])[CH2:14][NH:15][CH3:16])[C:9](=[O:24])[N:8]([CH:25]([CH3:27])[CH3:26])[C:7]=2[CH:6]=[CH:5][CH:4]=1.FC1C2N([C@@H](C3C=CC=CC=3)[C@H](O)CO)C(=O)N(C(C)C)C=2C=CC=1>>[ClH:1].[F:2][C:3]1[C:11]2[N:10]([CH:12]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:13]([OH:17])[CH2:14][NH:15][CH3:16])[C:9](=[O:24])[N:8]([CH:25]([CH3:27])[CH3:26])[C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 44254961HCID 44254961, compoundHCID 44255137HCID 44255137, compound

Product 1

HCID 68903007HCID 68903007, compound

Procedure

In an analogous manner to EXAMPLE 192, step 4 4-fluoro-3-[(1S,2R)-2-hydroxy-3-(methylamino)-1-phenylpropyl]-1-isopropyl-1,3-dihydro-2H-benzimidazol-2-one hydrochloride was prepared from 4-fluoro-3-[(1S,2S)-2,3-dihydroxy-1-phenyl-propyl]-1-isopropyl-1,3-dihydro-2H-benzimidazol-2-one as a white solid. MS (ES) m/z 358.4.

Sources & evidence

ORD record
ord-84eddc37ae81405e8c97c5ea2fa60f90
Source dataset
uspto-grants-2009_04
Patent number
US07517899B2

Reaction notes

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