反应详情

温度

90 °C

Benzenesulfonamide (157 mg, 1.00 mmol) was added to a 10% aqueous solution of sodium hydroxide (0.40 mL, 4.0 mmol). A solution of compound 24A (280 mg, 1.00 mmol) in acetone (1 mL) was then added. The reaction mixture was heated at 90° C. for 8 h then cooled to room temperature. Ice was added and the mixture was extracted with CH2Cl2. The combined organic layers were washed with water, dried and concentrated under reduced pressure. Purification by flash chromatography on silica gel, eluting with CH2Cl2 gave 60 mg (0.23 mmol, 23%) of compound 24B as yellow oil.

1. temperaturethen cooled to room temperature
2. additionIce was added
3. extractionthe mixture was extracted with CH2Cl2
4. washThe combined organic layers were washed with water
5. customdried
6. concentrationconcentrated under reduced pressure
7. customPurification by flash chromatography on silica gel
8. washeluting with CH2Cl2