HCID 21874892, compound → 5-Amino-3-fluoropyridine-2-carbonitrile

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Reaction Steps

2-Cyano-3-fluoro-5-nitropyridine (0.12 g, 0.72 mmol) and iron powder (0.21 g, 3.6 mmol, 325 Mesh) were reacted in 1:1 EtOAc/AcOH (10 mL) utilizing the procedure described in example 762D. Trituration of the crude product with ether gave compound 771D (0.093 g, 94%) as a pale yellow solid. HPLC: 99% at 1.27 min(YMC S5 ODS column) eluting with 10-90% aqueous methanol containing 0.2% phosphoric acid over a 4 min gradient monitoring at 220 nm. MS (ES): m/z 138.02 [M+H]+.

Provenance & Evidence