Calcium Chloride → 5-Amino-2-cyano-3,4-dimethylpyridine

HRID 2110483Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2110483
[C:1]([C:3]1[C:8]([CH3:9])=[C:7]([CH3:10])[C:6]([N+:11]([O-])=O)=[CH:5][N:4]=1)#[N:2].[Cl-].[Ca+2].[Cl-]>[Fe]>[NH2:11][C:6]1[C:7]([CH3:10])=[C:8]([CH3:9])[C:3]([C:1]#[N:2])=[N:4][CH:5]=1

Komponenten

4

Edukt 2

HCID 5284359Calcium ChlorideHCID 218752092-Cyano-3,4-dimethyl-5-nitropyridine

Produkt 1

HCID 218751095-Amino-2-cyano-3,4-dimethylpyridineAusbeute 50 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23925IronKatalysator

Versuchsvorschrift

2-Cyano-3,4-dimethyl-5-nitropyridine (0.15 g, 0.85 mmol), calcium chloride (0.05 g, 0.42 mmol), and iron powder (0.44 g, 7.8 mmol, 325 Mesh) were reacted as described in example 772B. Purification of the crude product by silica gel chomatography using 1:1 ether/CH2Cl2 as the eluent gave compound 773B (0.054 g, 50%) as a yellow solid.

Aufarbeitung

  1. customPurification of the crude product by silica gel chomatography

Quellen und Nachweise

ORD-Eintrag
ord-4861d9db239643a0becaf53fb85a57e4
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07517904B2

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