Sodium Methoxide → HCID 135414274, compound

Participants

Reaction Steps

A mixture of Example 1G (0.3 g, 0.55 mmol) in 30% weight sodium methoxide in methanol (3 mL) was stirred at 25° C. for 24 h. The solution was quenched with saturated NH4Cl, and extracted with ethyl acetate. The organic extract was concentrated in vacuo, extracted with ethyl acetate, and the organic layer was concentrated in vacuo. Column chromatography on silica (4% methanol/ethyl acetate) afforded the title compound as a white solid (0.095 g, 28.8%). 1H NMR (300 MHz, DMSO-d6) δ ppm 0.72 (m, 3H), 0.95-1.29 (m, 5H), 1.63 (m, 2H), 2.99 (s, 3H), 4.95 (s, 1H), 7.17-7.59 (m, 8H), 7.93 (d, J=7.35 Hz, 1H), 9.89 (s, 1H); MS(ESI) m/z 504.1 (M+H)+.

Provenance & Evidence