Hydrochloric Acid → HCID 178502615, compound

Participants

Reaction Steps

The product from Example 22C (60 mg, 0.15 mmol) in a 2:1 mixture of tetrahydrofuran:2N aq. HCl (0.9 mL) was stirred at rt for 3 h and concentrated in vacuo. The crude product was purified by column chromatography on silica gel using 2:1 ethyl acetate:hexanes to give the hydrochloride salt of the title compound as a colorless amorphous solid (42 mg, 87%): [α]D=+152° (c 1.4, methanol).

Provenance & Evidence