HCID 136396968, compound → HCID 136397087, compound

Participants

Reaction Steps

A mixture of Example 24B (12 mg, 0.018 mmol) and 10% Pd/C (2 mg) in methanol (1 mL) was hydrogenated at 1 atm for 1 h. The solution was filtered and the filtrate was concentrated in vacuo. Column chromatography on silica (7% methanol/dichloromethane) afforded the title compound (6 mg, 58%). 1H NMR (300 MHz, DMSO-d6) δ ppm 0.50-0.62 (m, 1H), 0.67 (dd, J=9.93, 6.62 Hz, 6H), 0.84-1.06 (m, 1H), 1.22-1.33 (m, 1H), 1.96 (s, 3H), 2.01-2.08 (m, 1H), 2.06-2.21 (m, 1H), 3.03 (s, 3H), 7.51 (m, 6H), 8.03 (d, J=8.09 Hz, 1H), 10.04 (s, 1H), 10.22 (s, 1H), 14.45-14.74 (br. s, 1H)); MS m/z 576.4 (M+H)+.

Provenance & Evidence