HCID 90741792, compound → HCID 68843005, compound

Participants

Reaction Steps

A solution of Example 40A (30 mg, 0.087 mmol) in methanol (0.2 mL) and 1 N NaOH (0.2 mL) was stirred at 25° C. for 16 hours. The methanol was evaporated. The resulted solution was acidified with 1N HCl to pH 3, extracted with ethyl acetate, dried (Na2SO4), and filtered. The filtrate was concentrated in vacuo to afforded the title compound (24 mg, 91%) and used for the next step without further purification. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.35-0.49 (m, 1H,) 0.69 (dd, J=13.05, 6.43 Hz, 6H), 0.77-0.96 (m, 1H), 1.24-1.36 (m, 1H), 1.83-1.94 (m, 1H), 2.04-2.22 (m, 1H), 3.18 (d, 1H), 3.67 (d, J=15.44 Hz, 1H), 5.76 (s, 1H), 7.45-7.55 (m, 1H), 7.59-7.73 (m, 2H), 7.90 (d, J=7.72 Hz, 1H), 11.83-12.71 (br. s, 1H); MS (ESI) m/z 304.9 (M+H)+.

Provenance & Evidence