HCID 137194559, compound → HCID 136396957, compound

Participants

Reaction Steps

A solution of Example 53B (15 mg, 0.024 mmol) in tetrahydrofuran (0.3 mL) and 1 N HCl (0.2 mL) was heated at 65° C. for 4 hours. The solution was cooled to room temperature and concentrated in vacuo. The residue was chromatographed on a reverse phase C18 column eluting with 5%-100% acetonitrile in water containing 0.1% trifluoroacetic acid to afforded the title compound as a yellow solid (4 mg, 28%). 1H NMR (300 MHz, DMSO-d6) δ ppm 0.46-0.61 (m, 1H), 0.67 (dd, J=12.50, 6.62 Hz, 6H, 0.93-1.05 (m, 1H), 1.16-1.40 (m, 1H), 1.69-1.90 (m, 1H), 1.96-2.16 (m, 1H), 3.11 (s, 3H), 4.46 (s, 2H), 7.43 (d, J=8.46 Hz, 1H), 7.56 (t, J=6.99 Hz, 1H), 7.61-7.73 (m, 2H), 7.73-7.91 (m, 2H), 8.16 (d, J=8.09 Hz, 1H), 10.45-10.75 (br.s, 1H), 12.91-13.14 (br.s, 1H), 14.50 (s, 1H); MS (ESI) m/z 593.0 (M+H)+.

Provenance & Evidence