Sulfuric Acid → HCID 135885187, compound

Participants

Reaction Steps

To a solution of the product from Example 8F (20 mg, 38 μmol) in CH3CN (0.2 mL) at 0° C. was added conc. H2SO4 (0.2 mL) dropwise. The resulting mixture was stirred at room temperature for 3 h and was poured onto ice (˜5 mL). The mixture was allowed to warm to room temperature, and the product was collected by filtration to give the title compound as an off-white solid (19 mg, 88%). 1H NMR (300 MHz, DMSO-d6) δ ppm 13.65 (br s, 1H), 10.26 (s, 1H), 9.15 (s, 1H), 8.12 (d, J=7.0 Hz, 1H), 7.69-7.79 (m, 2H), 7.47-7.65 (m, 4H), 3.06 (s, 3H), 2.50 (s, 3H), 1.74-2.06 (m, 2H), 0.84-1.00 (m, 1H), 0.66 (s, 9H), 0.39-0.58 (m, 1H).

Provenance & Evidence