Hydrochloric Acid → HCID 135885143, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product from Example 65 (62 mg, 0.11 mmol) in 1,4-dioxane (1 mL) was added 4N HCl (aq., 2 mL), and the resulting mixture was heated at 100° C. for 2 days. The cooled mixture was concentrated in vacuo, and was suspended in H2O to precipitate unreacted starting material. The filtrate was concentrated in vacuo to give the title compound as an off-white solid (27 mg, 44%). 1H NMR (300 MHz, DMSO-d6) δ ppm 14.44 (br s, 1H), 9.95 (s, 1H), 8.62 (br s, 2H), 8.13 (d, J=7.7 Hz, 1H), 7.59-7.74 (m, 2H), 7.48-7.59 (m, 2H), 7.42-7.48 (m, 1H), 7.33-7.39 (m, 1H), 3.01 (s, 3H), 1.94-2.12 (m, 1H), 1.76-1.94 (m, 1H), 1.01-1.18 (m, 1H), 0.70-0.80 (m, 1H), 0.69 (s, 9H).

Provenance & Evidence