HCID 135885194, compound → HCID 135885158, compound

Participants

Reaction Steps

A mixture of the product from Example 81 (13 mg, 0.018 mmol) and 10% Pd/C (3 mg) in methanol (1 mL) was stirred at room temperature under H2 atmosphere for 6 h. The heterogeneous solution was filtered and the filtrate was concentrated in vacuo. Column chromatography on silica (5% methanol/dichloromethane) afforded the title compound as a yellow solid (8 mg, 73%). 1H NMR (500 MHz, DMSO-d6) δ ppm 0.59-0.69 (m, 10H), 0.97-1.07 (m, 1H), 1.78-1.90 (m, 1H), 2.00-2.11 (m, 1H), 2.98 (s, 3H), 3.18 (d, J=12.21 Hz, 1H), 3.41 (d, J=12.21 Hz, 1H), 6.69 (d, J=7.93 Hz, 2H), 7.05 (d, J=8.54 Hz, 2H), 7.24 (d, J=8.54 Hz, 1H), 7.40-7.48 (m, 2H), 7.52-7.60 (m, 2H), 7.80 (d, J=7.93 Hz, 1H), 8.15 (d, J=7.32 Hz, 1H), 8.86 (s, 1H), 14.58 (s, 1H); MS m/z 639.3 (M+H)+.

Provenance & Evidence