Hydrochloric Acid → HCID 69062473, compound

Participants

Reaction Steps

To a solution of 3-{2-Methoxy-6-[2-(4-methoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-phenol [0.3 g, Example 35(p)] in EtOAc is added a saturated solution of hydrogen chloride in EtOAc (3 mL) and the resulting precipitate is filtered, and dried to afford 3-{2-methoxy-6-[2-(4-methoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-phenol hydrochloride [0.31 g, Example 15(a)] as a solid. LCMS: RT=2.55 minutes, MS: 352 (M+H). 1H NMR [(CD3)2SO]: δ 10.1 (1H, brs), 9.6 (1H, brs), 7.64-7.54 (1H, m), 7.34 (1H, t, J=8.1 Hz), 7.21-7.12 (4H, m), 7.02 (1H, d, J=7.5 Hz), 6.85 (2H, d, J=8.4 Hz), 6.67 (1H, s), 4.06 (3H, s), 3.71 (3H, s), 3.7-3.6 (2H, m), 2.85 (2H, t, J=7.2 Hz). IC50=0.1 nM

Provenance & Evidence