HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2110680Generated: November 2, 2026
Methanol → 4-Chloro-6-(3,4-dimethoxy-phenyl)-2-methoxy-pyrimidine
https://huagongshe.com/reaction/2110680
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 4-Chloro-6-(3,4-dimethoxy-phenyl)-2-methanesulfonyl-pyrimidine | HCID 57636140 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 4-Chloro-6-(3,4-dimethoxy-phenyl)-2-methoxy-pyrimidine | HCID 57636117 | 100% |
Reaction Steps
A mixture of 4-chloro-6-(3,4-dimethoxy-phenyl)-2-methanesulfonyl-pyrimidine [5.05 g, 0.0154 mol, Intermediate (49)] in ethylene glycol dimethyl ether (100 mL) is chilled to 0° C. and added 25 wt % sodium methoxide in MeOH (1.32 mL, 0.0231 mol). After 15 minutes the reaction is allowed to warm to ambient temperature and stirred overnight. The mixture is concentrated to afford 4-chloro-6-(3,4-dimethoxy-phenyl)-2-methoxy-pyrimidine [4.3 g, 100%, Intermediate (50)]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07517889B2 |
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| Source dataset | uspto-grants-2009_04 |
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| ORD ID | ord-a954a6ebcef3409b9e5d925b90d476f4 |
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| Source note | uspto-grants-2009_04 |
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