Hydrochloric Acid → HCID 69066223, compound

Participants

Reaction Steps

By proceeding in a similar manner to Example 43(b) but substituting 2-(6-methoxy-1H-indol-3-yl)-ethylamine for 2-(4-nitro-phenyl)-ethylamine, and substituting acetonitrile for EtOH as solvent in Step 3 there is prepared [2-(6-methoxy-1H-indol-3-yl)-ethyl]-[2-methoxy-6-(3-methoxy-phenyl)-pyrimidin-4-yl]-amine which is dissolved in ether and treated with 1 M hydrogen chloride in ether affording [2-(6-methoxy-1H-indol-3-yl)-ethyl]-[2-methoxy-6-(3-methoxy-phenyl)-pyrimidin-4-yl]-amine hydrochloride [58.6 mg, 66%, Example 43(g)] as a solid. LC/MS: RT=2.48 minutes MS: 405 (M+H). 1H NMR [300 MHz, (CD3)2SO]: □10.6 (1H, s), 7.3-7.5 (4H, m), 7.12 (1H, m), 7.02 (1H, m), 6.8 (1H, s), 6.61 (2H, m), 3.99 (3H, s), 3.8 (3H, s), 3.72 (3H, s), 3.58 (2H, m), 2.94 (2H, m). IC50=104 nM

Provenance & Evidence