Hydrochloric Acid → HCID 69064091, compound

Participants

Reaction Steps

By proceeding in a similar manner to Example 43(b) but substituting 3-phenyl-propylamine for 2-(4-nitro-phenyl)-ethylamine, and substituting acetonitrile for EtOH as solvent in Step 3 there is prepared [2-methoxy-6-(3-methoxy-phenyl)-pyrimidin-4-yl]-(3-phenyl-propyl)-amine which is dissolved in ether and treated with 1 M hydrogen chloride in ether affording [2-methoxy-6-(3-methoxy-phenyl)-pyrimidin-4-yl]-(3-phenyl-propyl)-amine hydrochloride [60.6 mg, 79%, Example 43(l)] as a solid. LC/MS: RT=2.65 minutes, MS: 350 (M+H). 1H NMR [300 MHz, (CD3)2SO]: □7.1-7.5 (9H, m), 6.62 (1H, s), 3.95 (3H, s), 3.8 (3H, s), 3.42 (2H, m), 2.64 (2H, m), 1.88 (2H, m). IC50=1686 nM

Provenance & Evidence