Triphenylphosphine → HCID 11494843, compound

Participants

Reaction Steps

To a solution of 2-methoxy-5-{2-methoxy-6-[2-(4-methoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzaldehyde oxime [0.49 g, 1.2 mmol, Example 26(c)], and triphenylphosphine (0.63 g, 2.4 mmol) in DCM (20 mL) is added N-chloro-succinimide (0.32 g, 2.4 mmol) at 10° C. After 2 hours at 20° C., the mixture is concentrated, and subjected to chromatography on silica gel eluting with 5% to 10% MeOH in DCM to afford 2-methoxy-5-{2-methoxy-6-[2-(4-methoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzonitrile [0.4 g, 85%, Example 55]. LCMS: RT=2.75 minutes, MS: 391 (M+H).

Provenance & Evidence