Ammonia → 2,2-Difluoro-2-phenylacetamide

HRID 2110727Notes

Reaction equation

HRID 2110727 reaction equation
C([O:3][C:4](=O)[C:5]([F:13])([F:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)C.[NH3:15]>CO>[F:12][C:5]([F:13])([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:4]([NH2:15])=[O:3]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 10631860Ethyl 2,2-difluoro-2-phenylacetate

Product 1

HCID 2696562,2-Difluoro-2-phenylacetamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the above difluoro-phenyl-acetic acid ethyl ester and NH3 in MeOH (7 M, 10 mL) is heated to 60° C. for 2 h in a pressure tube. The mixture is cooled to room temperature, and concentrated to afford 2,2-difluoro-2-phenyl-acetamide (0.33 g). LCMS: RT=1.7 minutes; MS: 172 (M+H).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-1fc31519b73d4a78941f5f46ae2a266f
Source dataset
uspto-grants-2009_04
Patent number
US07517889B2

Reaction notes

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