Methyl N-(triethylammoniosulfonyl)carbamate → HCID 86615703, compound

Participants

Reaction Steps

A mixture of 4-[2-(6-chloro-2-methoxy-pyrimidin-4-ylamino)-ethyl]-benzoic acid N′-acetyl-hydrazide (0.2 g, 0.55 mmol), and Burgess reagent (0.39 g, 1.65 mmol) in THF (6 mL) is placed in a microwave reactor. After 5 min at 130° C., the mixture is concentrated in a rotavap, and subjected to a chromatography eluting with 10% MeOH in CH2Cl2 to afford (6-chloro-2-methoxy-pyrimidin-4-yl)-{2-[4-(5-methyl-[1,3,4]oxadiazol-2-yl)-phenyl]-ethyl}-amine (160 mg). LCMS: RT=2.29 minutes; MS: 346 (M+H).

Provenance & Evidence