反应详情

A mixture of 4,6-dichloro-2-methoxy-pyrimidine (0.45 g, 2.5 mmol), C-isochroman-1-yl-methylamine (0.53 g, 3.2 mmol), and NaHCO3 (0.63 g, 7.5 mmol) in EtOH (5 mL) is heated to reflux for 4 h. The mixture is diluted with water, concentrated in vacuo. The residue is partitioned between EtOAc and water, and extracted with EtOAc. The extracts are dried (Na2SO4), and concentrated to afford (6-chloro-2-methoxy-pyrimidin-4-yl)-isochroman-1-ylmethyl-amine (0.84 g). LCMS: RT=2.94 minutes; MS: 306 (M+H).

1. temperatureis heated
2. temperatureto reflux for 4 h
3. concentrationconcentrated in vacuo
4. customThe residue is partitioned between EtOAc and water
5. extractionextracted with EtOAc
6. dry with materialThe extracts are dried (Na2SO4)
7. concentrationconcentrated