Sodium sulfate decahydrate → HCID 23111775, compound

Participants

Reaction Steps

To a solution (30 mL) of 3-(1-benzothiophen-3-yl)benzaldehyde (2.1 g, 8.81 mmol) in anhydrous tetrahydrofuran was added lithium aluminum hydride (0.37 g, 9.75 mmol) under ice-cooling, and the mixture was stirred at room temperature for 2 hr. The reaction solution was ice-cooled, sodium sulfate decahydrate (3.0 g, 5.74 mmol) was added, and the mixture was stirred at room temperature for 1 hr. The precipitated insoluble material was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (ethyl acetate:hexane=1:5-1:3) to give the title compound (2.0 g, yield 95%) as a colorless oil. 1H NMR (CDCl3) δ: 1.72 (1H, t, J=5.8 Hz), 4.80 (2H, d, J=5.8 Hz), 7.35-7.64 (7H, m), 7.88-7.98 (2H, m).

Provenance & Evidence