(2E)-3-(2,6-Difluoro-4-methoxyphenyl)-2-propenoic Acid Ethyl Ester → Ethyl 3-(2,6-difluoro-4-methoxyphenyl)propanoate

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Reaction Steps

Ethyl (2E)-3-(2,6-difluoro-4-methoxyphenyl)acrylate (1.1 g, 4.54 mmol) was dissolved in a mixed solvent of tetrahydrofuran (30 mL) and ethanol (30 mL), 10% palladium-carbon (50% water-containing product, 0.30 g) was added, and the mixture was stirred under a hydrogen atmosphere at room temperature for 5 hr. The catalyst was filtered off and the obtained filtrate was concentrated to give the title compound (1.17 g, yield 100%) as a colorless oil. MS: m/z 245 (MH+).

Provenance & Evidence